IMMUNOLOGY: Testing the Line Between Too Much and Too Little
نویسندگان
چکیده
منابع مشابه
Too much or too little
The global effort to understand the molecular drivers of cancer onset and progression is now coming to fruition with the identification of specific genomic and epigenomic events that influence signaling through key oncogenic pathways. Genetic studies using inducible expression of the critical growth controlling oncogenes MYC, RAS, PI3K and AKT have shown unequivocally that, in conjunction with ...
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You are going to Paul’s party tonight. You have a long day of work ahead of you before that, but you can’t wait to get there. Your annoying friend comes up to you and says, ‘Hi! Oh, are you going to Paul’s party tonight? I don’t think I’ll go. Unless your going?’ You reply, ‘I have to work.’ There are lies and then there are misleading utterances that are not lies. You did not lie to your frien...
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This paper provides a selective overview of the past, present and future of pediatric psychopharmacology. The acceptance of medication use in child psychiatry was based on the results of double-blind, placebo-controlled trials documenting the efficacy of drug treatments for attention-deficit/hyperactivity disorder, enuresis, depression, anxiety disorders, obsessive-compulsive disorder and psych...
متن کاملNot too much and not too little.
The structure and function of any protein is determined by its amino acid sequence. Thus, the substitution of one amino acid for another can alter the activity of a protein or its function. Mutations—or rather, polymorphism, once they become fixed in the population—can be deleterious, such that the altered protein is no longer able to fulfil its role with potentially devastating effects on the ...
متن کاملToo much PABP, too little translation.
Posttranscriptional regulation is of critical importance during mammalian spermiogenesis. A set of mRNAs that encode proteins critical to normal sperm formation are synthesized early in the process of male germ cell differentiation and are stored in a repressed state. These mRNAs are subsequently translationally activated during the process of spermatid elongation and maturation. Of note, the t...
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ژورنال
عنوان ژورنال: Science
سال: 2007
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.318.5851.740